Inria is the only French public research body fully dedicated to computational sciences. Throughout its 8 research centres and its 180 project teams, Inria has a workforce of 3,400 scientists with an annual budget of 265 million euros. MIMESIS research team at Inria focuses on creating a synergy between clinicians and scientists in order to develop new technologies capable of redefining healthcare, with a strong emphasis on clinical translation. They developed a partnership with the Institut Hospitalo-Universitaire- IHU on image-guided minimally invasive surgery. Over the past years they have developed new approaches supporting advanced simulations in the context of simulation for training. They now propose to focus our research on the use of real-time simulation for per-operative guidance. The underlying objectives include numerical techniques for real-time computation and data-driven simulation dedicated to patient-specific modeling. The main research topics are: Real-time patient-specific computational models ; Adaptive meshing and advanced simulation techniques and Image-driven simulation.